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Factors Contributing to Chemical Toxicity

 Factors Contributing to Chemical Toxicity



The ability of a drug to create negative effects is referred to as its toxicity. These effects can affect a single cell, a cell cluster, an organ system, or the entire body. A toxic effect can be obvious harm or a decline in performance or function that can only be measured with a test. All chemicals have the potential to cause harm. When just a very little amount of a chemical can cause harm, it is considered practically non-toxic. When even a small amount is dangerous, the chemical is termed highly toxic.

A substance's toxicity is determined by three factors: its chemical structure, the extent to which it is absorbed by the body, and the body's ability to detoxify (convert it into less harmful compounds) and eliminate it from the body.


No. The toxicity of a chemical refers to its ability to cause harm and is simply one consideration in establishing if a danger exists. A chemical's hazard is the practical possibility that it may cause harm. The following factors decide whether a chemical is hazardous:
  • Toxicity: the amount of a substance required to produce harm.
  • Exposition path: The manner in which the material enters your body,
  • Dose: The amount that enters your body.
  • Duration: The amount of time you are exposed for.
  • Interaction and reaction: Other drugs to which you are exposed at the same time, and
  • Sensitivity: How your body reacts to a drug in comparison to other people's bodies.  
Some compounds are hazardous due to the possibility of fire or explosion. These are significant risks, although they are regarded as non-toxic rather than toxic. The components of a hazardous hazard are discussed in greater detail below.


The chemical structure of a substance (what it is made of), the atoms and molecules it includes, and how they are ordered are the most essential factors in toxicity. Substances with comparable chemical structures frequently produce similar health issues. However, minor chemical variations exist.

The type of health effect produced can vary greatly depending on structure. For example, silica in one form (amorphous) has little effect on health and is permitted to be present in relatively high amounts in the workplace. When heated, however, it transforms into crystalline silica, which causes substantial lung damage at levels 200 times lower than amorphous silica.


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Ms. Divyasree  - HSE Adviser | Aim Vision Safety Training & Consulting

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